Salient features of the aza-Wacker cyclization reaction |
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Authors: | Annu Anna Thomas Someshwar Nagamalla Shyam Sathyamoorthi |
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Institution: | Department of Medicinal Chemistry, University of Kansas, Lawrence KS USA, |
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Abstract: | The intramolecular aza-Wacker reaction has unparalleled potential for the site-selective amination of olefins, but it is perhaps underappreciated relative to other alkene oxidations. The first part of this review makes the distinction between classical and tethered aza-Wacker cyclization reactions and summarizes examples of the latter. The second portion focuses on developments in asymmetric aza-Wacker cyclization technology. The final part of the review summarizes applications of all classes of aza-Wacker cyclization reactions to natural product assembly.The aza-Wacker cyclization reaction is a powerful strategy for alkene amination. |
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