Nickel-catalyzed three-component olefin reductive dicarbofunctionalization to access alkylborates |
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Authors: | Xiao-Xu Wang Xi Lu Shi-Jiang He Yao Fu |
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Institution: | Hefei National Laboratory for Physical Sciences at the Microscale, CAS Key Laboratory of Urban Pollutant Conversion, Anhui Province Key Laboratory of Biomass Clean Energy, iChEM, University of Science and Technology of China, Hefei 230026 China, |
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Abstract: | We report a three-component olefin reductive dicarbofunctionalization for constructing alkylborates, specifically, nickel-catalyzed reductive dialkylation and alkylarylation of vinyl boronates with a variety of alkyl bromides and aryl iodides. This reaction exhibits good coupling efficiency and excellent functional group compatibility, providing convenient access to the late-stage modification of complex natural products and drug molecules. Combined with alkylborate transformations, this reaction could also find applications in the modular and convergent synthesis of complex compounds.Nickel-catalyzed three-component olefin reductive dicarbofunctionalization for constructing alkylborates was achieved. |
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