The role of the t-SNARE SNAP-25 in action potential-dependent calcium signaling and expression in GABAergic and glutamatergic neurons |
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| Authors: | Lawrence CR Tafoya C William Shuttleworth Yuchio Yanagawa Kunihiko Obata Michael C Wilson |
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| Institution: | (1) Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, USA;(2) Department of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, Maebashi, Japan;(3) Neural Circuit Mechanisms Research Group, Obata Research Group, RIKEN Brain Science Institute, Wako, Japan |
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| Abstract: | Background The soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex, comprised of SNAP-25, syntaxin
1A, and VAMP-2, has been shown to be responsible for action potential (AP)-dependent, calcium-triggered release of several
neurotransmitters. However, this basic fusogenic protein complex may be further specialized to suit the requirements for different
neurotransmitter systems, as exemplified by neurons and neuroendocrine cells. In this study, we investigate the effects of
SNAP-25 ablation on spontaneous neuronal activity and the expression of functionally distinct isoforms of this t-SNARE in
GABAergic and glutamatergic neurons of the adult brain. |
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