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Review of molecular modification techniques for improved detection of biomolecules by mass spectrometry |
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| Authors: | Honda Aki Suzuki Yoshio Suzuki Koji |
| Affiliation: | a Department of Applied Chemistry, Keio University, 3-14-1 Hiyoshi, Kohoku, Yokohama, Kanagawa 223-8522, Japan b CREST of Japan Science and Technology, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan c Research Center of Advanced Bionics, National Institute of Advanced Industrial Science and Technology (AIST), c/o Katayanagi Advanced Research Laboratories, Tokyo University of Technology, 1404-1 Katakura, Hachioji, Tokyo 192-0982, Japan |
| Abstract: | After a soft ionizing method was established, MS (mass spectrometry) has become a more common tool in biochemistry because soft ionization made it possible to detect large molecules such as proteins. Many kinds of applications were established to further utilize MS for the identification or quantitation of biomolecules. In this review, we introduce recent applications with special focus on chemical modification techniques and chemical probes developed for the MS determination of biomolecules. |
| Keywords: | Mass spectrometry Chemical modification Mass probe Biomolecules |
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