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Non-catalytic conversion of C-F bonds of gem-difluoromethylene derivatives to C-H bonds with lithium aluminum hydride under room temperature |
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| Authors: | Jing-Jing WuJian-Hang Cheng Jian ZhangLi Shen Xu-Hong QianSong Cao |
| Affiliation: | Shanghai Key Laboratory of Chemical Biology, Center of Fluorine Chemical Technology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China |
| Abstract: | An unexpected hydrodefluorination of unactivated aliphatic C-F bonds of CF2 derivatives with LiAlH4 at room temperature without any added metal catalyst was reported. Deuterium-labeling experiments suggested that the hydrogens introduced into the products originated from LiAlH4. |
| Keywords: | C-F bond activation gem-Difluoromethylene derivatives Hydrodefluorination Lithium aluminum hydride Reduction |
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