| 6-取代吲哚喹嗪酮的1H NMR |
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| 引用本文： | 彭师奇,毛希安.6-取代吲哚喹嗪酮的1H NMR[J].波谱学杂志,1996,13(6):583-587. |
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| 作者姓名： | 彭师奇 毛希安 |
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| 作者单位： | 1. 北京医科大学生源药物化学中德联合实验室, 北京 100083;2. 中国科学院武汉物理研究所波谱与原子分子物理国家重点实验室, 武汉 430071;3. Institut fur Organische Chemie, Universitat Hannover, Germany |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 6位取代的3-乙酰基-1,4,6,7-四氢吲哚2,3-a]喹嗪-4-酮具有抗肿瘤活性,活性强度与6位取代基相关.本文报道了6-甲氧羰基、6-羰基、6-酰胺基、6-羟甲基和6-乙酰基乙酰氧甲基取代的3-乙酰基-1,4,6,7-四氢吲哚2,3-a]喹嗪-4-酮的1H NMR,比较了所述化合物的抗HL60活性与某些质子的化学位移的关系.
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| 关 键 词： | 吲哚喹嗪酮 1H NMR 抗HL60活性 |
| 收稿时间： | 1996-06-06 |
THE 1H NMR OF 6-SUBSTITUTED INDOLOQUINOLIZIDONES |
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| Peng Shiqi,Guo Ming,Mao Xian,Ekkehard Winterfeldt.THE 1H NMR OF 6-SUBSTITUTED INDOLOQUINOLIZIDONES[J].Chinese Journal of Magnetic Resonance,1996,13(6):583-587. |
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| Authors: | Peng Shiqi Guo Ming Mao Xian Ekkehard Winterfeldt |
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| Institution: | 1. College of Pharmaceutical Sciences, Beijing Medical University, Beijing 100083;2. State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute, The Chines. Academy of Sciences, Wuhan 430071;3. Institut fur Organische Chemie, Universitat Hannover, Germany |
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| Abstract: | The 6-substituted 3-acety1-1,4,6,7-tetrahydro-4-oxoindolo-2,3-a]quinolizines exhibited antitumer activity and the potency related to 6-substituent.In the present paper 6-methoxycarbonyl-,6-carboxy-,6-amido-,6-hydroxymethyl-and 6-acetylacetomethy1-3-acety1-1,4,6,7-tetrahydro-4-oxoindolo2,3-a] quinolizine were synthesized,their 1H NMR are reported,the relationships between HL60 inhibitions and the chemical shifts for some protons are discussed. |
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| Keywords: | Indoloquinolizidone 1H NMR Antitumer activity |
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