| (R)-N-(β-三氯锗取代丙酰基)TTCA酯的合成及其倍半氧化物 |
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| 引用本文： | 李叶芝,郭纯孝,张斌,王德平,黄化民.(R)-N-(β-三氯锗取代丙酰基)TTCA酯的合成及其倍半氧化物[J].有机化学,1998,18(3):235-240. |
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| 作者姓名： | 李叶芝 郭纯孝 张斌 王德平 黄化民 |
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| 作者单位： | 吉林大学化学系 长春130023
(李叶芝，郭纯孝，张斌，王德平)，吉林大学化学系 长春130023(黄化民) |
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| 基金项目： | 国家自然科学基金，吉林大学超分子结构与谱学开放实验室资助 |
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| 摘 要： | β-三氯锗取代丙酰氯1a～1c与(R)TTCA酯反应, 得到光学活性的(R)-N-(β-三氯锗取代丙酰基)TTCA酯3a～3d(α]D^2^0-86.00～-94.35ⅲ)及光学活性的β-三氯锗取代丙酰氯2a～2d。化合物3a～3d经水解得到(R)-N-(β-取代丙酰基)TTCA酯基锗倍半氧化物4a～4d, α]D^2^0-44.48～-77.00ⅲ。用半经验量子化学MNDO方法研究了反应物和产物最优构型的电子结构及反应的焓变。
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| 关 键 词： | 噻唑 P 红外分光光度法 元素分析 羧酸酯 电子结构 酰氯 P 有机锗化合物 硫酮 P |
Synthesis of the (R)-N-(β-trichlorogermyl substituted propionyl) TTCA ethers and their sesquioxides |
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| LI Ye - Zhi,GUO Chun - Xiao,ZHANG Bin,WANG De - Ping,HUANG Hua - Min.Synthesis of the (R)-N-(β-trichlorogermyl substituted propionyl) TTCA ethers and their sesquioxides[J].Chinese Journal of Organic Chemistry,1998,18(3):235-240. |
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| Authors: | LI Ye - Zhi GUO Chun - Xiao ZHANG Bin WANG De - Ping HUANG Hua - Min |
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| Abstract: | The (R) - N - (B- trichlorogermyl substituted propionyl)thiazolidine - 2 - thione - 4 - carboxylic acid ethers (R) - N - (B- trichlorogermyl substituted propionyl)TTCA ethers]3a~
3d, a]20D-86.00-- 94.35 and optically active B- trichlorogermyl substituted propionyl chloride 2a
--2d were synthesized by the reaction of trichlorogermyl substituted propionyl chloride with (R) -thiazolidine - 2 - thione - 4 - carboxylic acid ethers ( R )TTCA ethers]. The (R ) - N - (substituted propionyl thiazolidine - 2 - thione - 4 - alkyloxycarbonyl) germanium sesquioxides 4a~4d, a]20D
- 44.48--77.00 were obtained by the hydrolysis of compounds 3a~3d. The electronic structure of
reactants and products have been studied by quantum chemisty MNDO method. Reactive enthalpy H have been obtained. |
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| Keywords: | THIAZOLE P INFRARED SPECTROPHOTOMETRY ELEMENTAL ANALYSIS CARBOXYLIC ACID ESTER ELECTRONIC STRUCTURE ACYL CHLORIDES P ORGANO GERMANIUM |
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