| 2-氨基-3-羟基环戊烯-1-腈衍生物的合成和晶体结构 |
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| 引用本文： | 史达清,屠树江,高原,戴桂元.2-氨基-3-羟基环戊烯-1-腈衍生物的合成和晶体结构[J].有机化学,1998,18(5):456-461. |
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| 作者姓名： | 史达清 屠树江 高原 戴桂元 |
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| 作者单位： | 徐州师范大学化学系 徐州221009
(史达清，屠树江，高原)，徐州师范大学化学系 徐州221009(戴桂元) |
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| 摘 要： | 用低价钛试剂(TiCl~4-Zn)与α,α-(4-氯苯基)(二氰甲基)甲基苯基酮反应合成了非对映消旋体(3R,5S;3S,5R)和(3R,5R;3S,5S)2-氨基-3-羟基-3-苯基-5-对氯苯基环戊烯-1-腈。并用X射线衍射分析确定了这两个非对映异构体的构型。
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| 关 键 词： | 环烯腈 环戊烯P 氨基腈 晶体结构 构型 合成 钛试剂 氯化钛 二苯乙醇酮P 氯苯P |
Synthesis and crystal structure of 2-amino-3- hydroxycyclopentene-1- carbonitrile derivatives |
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| SHI Da - Qing,TU Shu - Jiang,GAO Yuan,DAI Gui - Yuan.Synthesis and crystal structure of 2-amino-3- hydroxycyclopentene-1- carbonitrile derivatives[J].Chinese Journal of Organic Chemistry,1998,18(5):456-461. |
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| Authors: | SHI Da - Qing TU Shu - Jiang GAO Yuan DAI Gui - Yuan |
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| Institution: | Xuzhou Teachers Coll, Dept Chem.Xuzhou(221009) |
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| Abstract: | The diastereomeric racemates(3R,5S;3S,5R) and (3R,5R;3S,5S) 2- amino - 3 -hydroxy - 3 - phenyl - 5 - (4' - chlorophenyl) cyclopentene - 1 - carbonitriles were synthesized by reaction of low - valent titanium reagent (TiCl4 - Zn) with a, a - (4 - chlorophenyl) (dicyanomethyl) methyl phenyl ketone. Their configurations were determined by X - ray analysis. |
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| Keywords: | low - valent titanium reagent 2 - amino - 3 - hydroxycyclopentene - 1 - carbonitrile synthesis crystal structure configuration |
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