二联苯和氨基酸构建的大环化合物自组装研究

以二联苯作为模板,设计并合成了3个二联苯和氨基酸构建的大环化合物.晶体结构结果研究发现,在固态,这些大环化合物分别组装成了管状、三维网状和链状的超分子结构,其中,C-H…O氢键在维持这些大环的组装方面发挥了重要作用.这将有助于进一步增加对分子自组装、分子识别以及生物大分子的稳定性方面的理解.

Self-assembly of Biphenyl-bridged and Amino Acid-based Macrocycle Compounds

As part of our efforts aimed at developing molecular receptors and peptide conformational templates, we have conducted a research on design, synthesis, and application of structurally modified cyclopeptides. In this paper, we disigned and synthesized three biphenyl-bridged, amino acid-based macrocycles. The investigation of crystallograghic structures reveals that in the solid state, these macrocycles were assembled into twin-tube, 3D network and chain-like supramolecular structures, respectively, in which the C-H...O hydrogen-bonds play important roles. These findings may be helpful for understanding the role of the C-H...O hydrogen bonding in determining crystal packing, molecular recognition, and the structural stability of biological macromolecules.