The Cooperative Effect of Both Molecular and Supramolecular Chirality on Cell Adhesion |
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Authors: | Jinying Liu Feng Yuan Xiaoyu Ma Dang‐i Y Auphedeous Changli Zhao Chuntai Liu Changyu Shen Prof Chuanliang Feng |
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Institution: | 1. State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, China;2. National Engineering Research Center for Advanced Polymer Processing Technologies, Zhengzhou University, Zhengzhou, China |
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Abstract: | Although helical nanofibrous structures have great influence on cell adhesion, the role played by chiral molecules in these structures on cells behavior has usually been ignored. The chirality of helical nanofibers is inverted by the odd–even effect of methylene units from homochiral l ‐phenylalanine derivative during assembly. An increase in cell adhesion on left‐handed nanofibers and weak influence of cell behaviors on right‐handed nanofibers are observed, even though both were derived from l ‐phenylalanine derivatives. Weak and negative influences on cell behavior was also observed for left‐ and right‐handed nanofibers derived from d ‐phenylalanine, respectively. The effect on cell adhesion of single chiral molecules and helical nanofibers may be mutually offset. |
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Keywords: | cell adhesion chirality inversion methylene unit odd– even effect supramolecular chemistry |
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