Brønsted Acid Enabled Nickel‐Catalyzed Hydroalkenylation of Aldehydes with Styrene and its Derivatives |
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| Authors: | Xing‐Wang Han Tao Zhang Yan‐Long Zheng Wei‐Wei Yao Jiang‐Fei Li You‐Ge Pu Prof?Dr Mengchun Ye Qi‐Lin Zhou |
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| Institution: | 1. State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin, China;2. Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, China |
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| Abstract: | A Brønsted acid enabled nickel‐catalyzed hydroalkenylation of aldehydes and styrene derivatives has been developed. The Brønsted acid acts as a proton shuttle to transfer a proton from the alkene to the aldehyde, thereby leading to an economical and byproduct‐free coupling. A series of synthetically useful allylic alcohols were obtained through one‐step reactions from readily available styrene derivatives and aliphatic aldehydes in up to 88 % yield and with high linear selectivity. |
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| Keywords: | aldehydes alkenes Brø nsted acids hydroalkenylation nickel |
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