| 硅胶固载硫酸镧催化一锅法合成3,4-二氢嘧啶-2(1H)-酮 |
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| 引用本文： | 陈勇,江洪.硅胶固载硫酸镧催化一锅法合成3,4-二氢嘧啶-2(1H)-酮[J].化学研究,2011,22(3):44-47,60. |
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| 作者姓名： | 陈勇 江洪 |
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| 作者单位： | 1. 常州大学石油化工学院,江苏常州,213161
2. 华中农业大学化学系,湖北武汉,430070 |
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| 摘 要： | 以硅胶固载硫酸镧作为催化剂,由芳香醛、β-酮酸酯和脲(硫脲)合成了相应的3,4-二氢嘧啶-2(1H)-酮化合物,考察了苯甲醛、乙酰乙酸乙酯、脲三组分发生Biginelli反应时的催化剂用量、反应物物质的量比、反应时间及催化剂重复使用对反应收率的影响;并利用核磁共振谱(1H NMR)和红外光谱(IR)表征了合成产物的结构...
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| 关 键 词： | 硅胶固载硫酸镧 3 4-二氢嘧啶-2(1H)-酮 Biginelli反应 一锅法合成 |
One-pot synthesis of 3,4-dihydropyrimidine-2 ( 1H)-ones catalyzed by lanthanum sulfate supported on silica gel |
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| CHEN Yong,JIANG Hong.One-pot synthesis of 3,4-dihydropyrimidine-2 ( 1H)-ones catalyzed by lanthanum sulfate supported on silica gel[J].Chemical Research,2011,22(3):44-47,60. |
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| Authors: | CHEN Yong JIANG Hong |
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| Institution: | 1.College of Petroleum and Chemical Engineering,Changzhou University,Changzhou 213164,Jiangsu,China;2.Department of Chemistry,Huazhong Agricultural University,Wuhan 430070,Hubei,China) |
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| Abstract: | A series of 3,4-dihydropyrimidine-2（1H）-ones were synthesized from aromatic aldehydes,β-ketoesters and urea or thiourea in the presence of lanthanum sulfate supported on silica gel as the catalyst.The effects of mole ratio of reactants,reaction time and catalyst on the yield of 3,4-dihydropyrimidin-2（1H）-ones via three-component Biginelli reaction of benzaldehyde,ethyl acetoacetate,and urea were investigated.The products were characterized by means of nuclear magnetic resonance（1H NMR） spectroscopy and infrared spectrometry（IR）.It has been found that the present synthetic route,as compared with classical Biginelli reaction,has the advantages of mild condition,high yield,simple operation,and environmental acceptance;and the catalyst can be easily isolated and reused several times without significant decrease in yield. |
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| Keywords: | lanthanum sulfate supported on silica gel 3 4-dihydropyrimidine-2（1H）-ones Biginelli reaction one-pot synthesis |
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