A copper- and amine-free sonogashira reaction employing aminophosphines as ligands |
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Authors: | Cheng Jiang Sun Yanhui Wang Feng Guo Minjie Xu Jian-Hua Pan Yi Zhang Zhaoguo |
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Institution: | Department of Chemistry, Nanjing University, 22 Hankou Road, Nanjing 210093, China. |
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Abstract: | An efficient Pd-catalyzed Sonogashira coupling reaction was achieved in the absence of a copper salt or amine with an inorganic base and easily prepared, air-stable aminophosphine ligands in commonly used organic solvents; good to excellent yields were obtained. Under optimized reaction conditions, the Sonogashira coupling reaction occurred selectively when an enyne substrate was employed and no Heck reaction product was detected; acetone-masked acetylene and trimethylsilylacetylene can also be efficiently coupled, providing a method to make terminal alkynes. |
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