Synthetic studies toward amphidinolide B1: synthesis of the C9-C26 fragment |
| |
| Authors: | Zhang Wei Carter Rich G |
| |
| Institution: | Department of Chemistry, 153 Gilbert Hall, Oregon State University, Corvallis, Oregon 97331, USA. |
| |
| Abstract: | reaction: see text] The synthesis of the C9-C26 portion of amphidinolide B1 is described. A Fleming allylation followed by elimination was employed for the construction of the C13-C15 diene portion. Sharpless asymmetric dihydroxylation was utilized for regioselective functionalization of a styrene-derived alkene, in the presence of the C13-C15 diene functionality. A highly diastereoselective aldol reaction was developed to establish the C18 stereochemistry. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
