The first synthesis and cytostatic activity of novel 6-(fluoromethyl)purine bases and nucleosides |
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| Authors: | Silhár Peter Pohl Radek Votruba Ivan Hocek Michal |
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| Institution: | Centre for New Antivirals and Antineoplastics, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nam. 2, CZ-16610, Prague 6, Czech Republic. |
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| Abstract: | Two alternative approaches to the synthesis of novel 6-(fluoromethyl)purine bases and nucleosides are described either by direct deoxyfluorination or by multistep functional group transformations starting from 6-(hydroxymethyl)purines. 6-(fluoromethyl)purine ribonucleoside displayed significant cytostatic effects. |
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