Chemoselective Synthesis of β‐Amino Ester or β‐Lactam via Sonochemical Reformatsky Reaction |
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| Authors: | Adam Shih‐Yuan Lee Yu‐Ting Chang Feng‐Yi Su |
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| Institution: | Department of Chemistry, Tamkang University, Tamsui, New Taipei, Taiwan |
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| Abstract: | A series of β‐amino esters were synthesized by the reaction of N‐tosyl aldimine or N‐hydroxy aldimine with bromoacetate by sonochemical Reformatsky reaction. The β‐N‐hydroxyamino ester was obtained and the formed sensitive hydroxylamino functionality was resistant under the reaction condition. The β‐lactam also was synthesized by the reaction of N‐p‐methoxy aldimine as reacting substrate under this sonochemical Reformatsky reaction condition. |
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| Keywords: | Sonochemical Reformatsky reaction N‐Hydroxy aldimine β ‐N‐Hydroxyamino ester β ‐Lactam |
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