Formation of pyrazine derivatives from D-glucosamine and their deoxyribonucleic acid (DNA) strand breakage activity |
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| Authors: | K Sumoto M Irie N Mibu S Miyano Y Nakashima K Watanabe T Yamaguchi |
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| Institution: | Faculty of Pharmaceutical Sciences, Fukuoka University, Japan. |
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| Abstract: | Two pyrazine derivatives fructosazine (3) and deoxyfructosazine (6)] were simultaneously formed in a solution of D-glucosamine hydrochloride under various conditions. They showed deoxyribonucleic acid (DNA) strand breakage activity in plasmid pBR322 comparable to that of D-glucosamine. The DNA strand breakage by fructosazine (3) was stimulated by Cu2+. |
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