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SAMBADENA Hyperpolarization of 13C-Succinate in an MRI: Singlet-Triplet Mixing Causes Polarization Loss |
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| Authors: | Stephan Berner Andreas B Schmidt Mirko Zimmermann Dr Andrey N Pravdivtsev Dr Stefan Glöggler Prof Dr Dr hc Jürgen Hennig PD Dr Dominik von Elverfeldt Prof Dr Jan-Bernd Hövener |
| Institution: | 1. Department of Radiology, Medical Physics, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Killianstraße 5a, 79106 Freiburg, Germany;2. Department of Radiology, Medical Physics, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Killianstraße 5a, 79106 Freiburg, Germany
Department of Radiology and Neuroradiology, Section Biomedical Imaging, MOIN CC, University Medical Center Schleswig-Holstein, University of Kiel, Am Botanischen Garten 14, 24118 Kiel, Germany;3. Department of Radiology and Neuroradiology, Section Biomedical Imaging, MOIN CC, University Medical Center Schleswig-Holstein, University of Kiel, Am Botanischen Garten 14, 24118 Kiel, Germany;4. Max Planck Institute for Biophysical Chemistry Am Fassberg 11, 37077 Göttingen, Germany Center for Biostructural Imaging of Neurodegeneration, Von-Siebold-Straße 3a, 37075 Göttingen, Germany |
| Abstract: | The signal enhancement provided by the hyperpolarization of nuclear spins of biological molecules is a highly promising technique for diagnostic imaging. To date, most 13C-contrast agents had to be polarized in an extra, complex or cost intensive polarizer. Recently, the in situ hyperpolarization of a 13C contrast agent to >20 % was demonstrated without a polarizer but within the bore of an MRI system. This approach addresses some of the challenges of MRI with hyperpolarized tracers, i. e. elevated cost, long production times, and loss of polarization during transfer to the detection site. Here, we demonstrate the first hyperpolarization of a biomolecule in aqueous solution in the bore of an MRI at field strength of 7 T within seconds. The 13C nucleus of 1-13C, 2,3-2H2-succinate was polarized to 11 % corresponding to a signal enhancement of approximately 18.000. Interesting effects during the process of the hydrogenation reaction which lead to a significant loss of polarization have been observed. |
| Keywords: | nuclear magnetic resonance hyperpolarization parahydrogen biomolecules succinate derivatives |