Highly regio- and stereoselective Michael addition of pseudouridine with propiolates: An efficient method for the synthesis of (E)-pseudouridine-N1-acrylate |
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| Authors: | Muthian Shanmugasundaram Annamalai Senthilvelan Anilkumar R Kore |
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| Institution: | Life Sciences Solutions Group, Thermo Fisher Scientific, 2130 Woodward Street, Austin, TX 78744-1832, USA |
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| Abstract: | The Michael addition of pseudouridine with various propiolates in the presence of DBU as a base and DMF as a solvent is described. It is noteworthy that the reaction is highly regio- and stereoselective and affords (E)-pseudouridine-N1-acrylate in good yields with high purities. |
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| Keywords: | Pseudouridine Propiolate RNA Michael addition |
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