Palladium catalyzed domino C-H activation strategy: An access to 9- fluorenones |
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| Authors: | Anuj Patel Mahommedumar Shaikh Kishor Chikhalia |
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| Institution: | 1. Department of Chemistry, Gujarat University, Ahmedabad, Gujarat, 38009 India;2. Department of Chemistry, Veer Narmad South Gujarat University, Surat, Gujarat, 395007 India |
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| Abstract: | Palladium catalyzed domino C-H functionalization reaction of arylaldehyde with dihaloarene has been developed to access 9-flourenone molecules. Bidentate ligand assisted strategy, single step reaction, high yield and excellent functional group tolerance make this method concise and effective for the synthesis of 9-flourenone. In addition, proposed method has been successfully employed to synthesise Tilorone in gram scale. |
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| Keywords: | Domino C-H activation 9-Fluorenone Palladium catalyst Tilorone synthesis |
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