| 两亲性树枝状大分子作为药物缓释载体的研究 |
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| 引用本文： | 李金娜,刘丛丛,王大伟,张堃,杨凤英,齐林双,王永健.两亲性树枝状大分子作为药物缓释载体的研究[J].离子交换与吸附,2011,27(4). |
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| 作者姓名： | 李金娜 刘丛丛 王大伟 张堃 杨凤英 齐林双 王永健 |
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| 作者单位： | 1. 南开大学生命科学学院,生物活性材料教育部重点实验室,天津300071
2. 南开大学化学学院高分子化学研究所,天津,300071 |
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| 基金项目： | 国家重点基础研究发展计划(973计划)(2011CB606202); 天津市应用基础研究计划项目(07JCYBJC02700) |
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| 摘 要： | 利用胆酸对1代聚酰胺-胺树枝状大分子进行修饰,得到两亲性树枝状大分子(PAMAM1-CA6)。采用1H-NMR和酸碱滴定法测得每个1代PAMAM分子上共价键连了6个胆酸分子。PAMAM1-CA6在水相中自组装成纳米粒子,粒径约为273nm。以抗癌药物氨甲喋呤为模型考察了此两亲性树枝状大分子对药物的缓释行为。在碱性条件下(pH=10),PAMAM1-CA6对氨甲喋呤的释放较为缓慢;随着溶液pH的降低,药物的释放速率明显加快。说明PAMAM1-CA6对氨甲喋呤的释放具有环境响应性。体外细胞实验的结果表明,PAMAM1-CA6能够显著地提高氨甲喋呤的疗效。因此,这类由低代树枝状大分子制得的材料有望成为新型的药物控释载体。
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| 关 键 词： | 胆酸 PAMAM MTX 缓释 自组装 |
NANOVEHICLES FOR ANTICANCER DRUG DELIVERY BASED ON AMPHIPHILIC DENDRIMERS |
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| LI Jinna,LIU Congcong,WANG Dawei,ZHANG Kun,YANG Fengying,QI Linshuang,WANG Yongjian.NANOVEHICLES FOR ANTICANCER DRUG DELIVERY BASED ON AMPHIPHILIC DENDRIMERS[J].Ion Exchange and Adsorption,2011,27(4). |
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| Authors: | LI Jinna LIU Congcong WANG Dawei ZHANG Kun YANG Fengying QI Linshuang WANG Yongjian |
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| Institution: | LI Jinna1 LIU Congcong1 WANG Dawei1 ZHANG Kun2 YANG Fengying1 QI Linshuang1 WANG Yongjian1 1.Key Laboratory of Bioactive Materials(Ministry of Education),College of Life Sciences,Nankai University,Tianjin 300071,China 2.College of Chemistry,Institute of Polymer Chemistry,Nankai University Tianjin 300071,China |
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| Abstract: | The amphiphilic dendrimers(PAMAM1-CA6) were prepared by cholic acid and the first generation polyamidoamine(G1 PAMAM) dendrimers.Six cholic acid molecules were linked to one G1 PAMAM which was determined by 1H-NMR and acid-base titration.The modified PAMAM dendrimers self-assembled to form dendritic multimolecular micelles in aqueous solutions,with a hydrodynamic diameter of about 273nm measured by dynamic light scattering.The potential of the amphiphilic dendrimers as an anticancer drug carrier was evaluat... |
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| Keywords: | Cholic acid PAMAM MTX Controlled release Self-assemble |
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