Enantioselective organocatalytic reductive amination |
| |
Authors: | Storer R Ian Carrera Diane E Ni Yike MacMillan David W C |
| |
Institution: | Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA. |
| |
Abstract: | The first enantioselective organocatalytic reductive amination reaction has been accomplished. The development of a new chiral phosphoric acid catalyst has provided a convenient strategy for the enantioselective construction of protected primary amines and provided a highly stereoselective method for the reductive amination of heterocyclic amines. A diverse spectrum of ketone and amine substrates can be accommodated in high yield and excellent enantioselectivity. This new protocol realizes a key benefit of reductive amination versus imine reduction, in that ketimines derived from alkyl-alkyl ketones are unstable to isolation, a fundamental limitation that is comprehensively bypassed using this direct organocatalytic reductive amination. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|