Synthesis and Biological Activities of N—Phosphory Branched Peptides |
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作者姓名: | ShengLiCAO YuYangJIANG YuPingFENG YanLingNIU YuFenZHAO |
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作者单位: | KeyLaboratoryofBioorganicPhosphorusChemistry,MinistryofEducation;DepartmentofChemistry,TsinghuaUniversity,Beijing100084 |
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摘 要: | A series of N-phosphoryl branched peptides were synthesized by coupling of various N-phosphoryl amino acids to L-Lysine methyl ester,and their structures were confirmed by ^31PNMR,^1H NMR,MS and elemental analysis.The results of cell biological tests indicated that compound 1d and 1e obviously inhibites the growth of both k562 and A2780 cells.
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关 键 词: | 磷酰基枝化缩氨酸 合成 性质 生物活性 |
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