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Asymmetric synthesis of 4,4-disubstituted-2-imidazoli-dinones: potent NK1 antagonists |
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| Authors: | Reichard Gregory A Stengone Carmine Paliwal Sunil Mergelsberg Ingrid Majmundar Sapna Wang Cheng Tiberi Robert McPhail Andrew T Piwinski John J Shih Neng-Yang |
| Institution: | Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA. |
| Abstract: | structure: see text] A highly efficient and practical synthesis of 4,4-Disubstituted-2-Imidazolidinones utilizing a "self-reproduction of the center of chirality" strategy is described. |
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