|
|||||
|
|
Study of the effect of atorvastatin on the interaction between ICAM-1 and CD11b by live-cell single-molecule force spectroscopy |
|
| Authors: | LI Yi SHI XiaoLi LIU HuiLiang YI ShaoQiong ZHANG XueJie & FANG XiaoHong |
| Institution: | LI Yi1,SHI XiaoLi2,LIU HuiLiang1,YI ShaoQiong3,ZHANG XueJie2 & FANG XiaoHong2 1Department of Cardiology,the General Hospital of Chinese People's Armed Police Forces,Beijing 100039,China,2Beijing National Laboratory for Molecular Sciences,Institute of Chemistry,Chinese Academy of Sciences,Beijing 100190,3State Key Laboratory of Pathogen , Biosecurity,Beijing Institute of Microbiology , Epidemiology,Beijing 100071 |
| Abstract: | The interaction between the cell adhesion molecule CD11b and its ligand ICAM-1 plays an important role in inflammatory responses in the disease of atherosclerosis. Atorvastatin is a commonly prescribed statin drug which has been considered as one of the most potent therapeutic agents for atherosclerosis due to its lipid-lowering effect. Recently, there is a growing body of evidence that atorvastatin has anti-inflammatory effect. We have applied the advanced method of live-cell single-molecule force spectros... |
| Keywords: | atherosclerosis atorvastatin atomic force microscopy single-molecule force spectroscopy protein-protein interaction |
| 本文献已被 CNKI 等数据库收录！ | |