| 微尺度色谱通道截面形状优化 |
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| 引用本文： | 闫孝红,Bau Haim H,王秋旺.微尺度色谱通道截面形状优化[J].工程热物理学报,2012(3):505-508. |
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| 作者姓名： | 闫孝红 Bau Haim H 王秋旺 |
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| 作者单位： | 西安交通大学化学工程系;宾夕法尼亚大学机械工程与应用力学系;西安交通大学热流科学与工程教育部重点实验室 |
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| 基金项目： | 国家自然科学杰青基金(No.51025623);中国留学基金(No.2008628024);美国自然科学基金(No.0822723) |
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| 摘 要： | 本文将基于体积平均方法的理论模型与拓扑优化工具结合,以减小弥散系数为优化目标对微尺度色谱通道的截面形状进行了优化。优化结果表明色谱通道截面形状优化可以明显削弱通道内弥散过程。优化得到的截面形状明显不同于常见的矩形截面,具体形状取决于流动阻力系数的数值,流动阻力系数越大,截面的宽高比越大。将优化截面用于微尺度色谱设计可以显著改善分离速度及分离精度。
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| 关 键 词： | 色谱 弥散 优化 截面形状 |
Shape Optimization of the Microscale Open Channel Chromatography |
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| YAN Xiao-Hong,Bau Haim H,WANG Qiu-Wang.Shape Optimization of the Microscale Open Channel Chromatography[J].Journal of Engineering Thermophysics,2012(3):505-508. |
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| Authors: | YAN Xiao-Hong Bau Haim H WANG Qiu-Wang |
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| Institution: | 1.Department of Chemical Engineering,Xi’an Jiaotong University,Xi’an 710049,China; 2.Department of Mechanical Engineering and Applied Mechanics,University of Pennsylvania,Philadelphia 19104,USA; 3.Key Laboratory of Thermo-Fluid Science and Engineering.MOE,Xi’an Jiaotong University,Xi’an 710049,China) |
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| Abstract: | Based on the theoretical model of the volume averaging method,the cross sectional shape of microscale open channel chromatography is optimized to minimize the dispersion coefficient using a topological optimization tool.It is found that,the dispersion can be obviously weakened by the shape optimization.The optimal shape is different from the common rectangular cross section,which depends on the flow resistance coefficient.Larger flow resistance coefficient corresponds to larger width to height ratio of the optimal shape.It is expected that the separation speed and separation accuracy can be markedly improved using the optimal shape for the design of microscale open channel chromatography. |
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| Keywords: | chromatography dispersion optimization cross sectional shape |
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