| 新型吲哚抗癌试剂的设计与合成 |
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| 引用本文： | 石常青,林文清,陈元伟. 新型吲哚抗癌试剂的设计与合成[J]. 合成化学, 2007, 15(4): 454-458 |
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| 作者姓名： | 石常青 林文清 陈元伟 |
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| 作者单位： | 中国科学院,成都有机化学研究所,不对称合成与手性技术四川省重点实验室,四川,成都,610041;中国科学院,研究生院,北京,100049;中国科学院,成都有机化学研究所,不对称合成与手性技术四川省重点实验室,四川,成都,610041 |
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| 基金项目： | 中国科学院"百人计划" |
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| 摘 要： | 以邻碘苯胺和苯乙炔为原料,经10步反应合成了2,3-二取代的新型吲哚抗癌试剂,总收率33%~37%,其结构经1H NMR和MS表征。
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| 关 键 词： | 抗癌试剂 吲哚 设计 药物合成 |
| 文章编号： | 1005-1511（2007）04-0454-05 |
| 收稿时间： | 2007-04-23 |
| 修稿时间： | 2007-04-23 |
Design and Synthesis of Novel Indole Derivatives as Anticancer Agent |
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| SHI Chang-qing,LIN Wen-qing,CHEN Yuan-wei. Design and Synthesis of Novel Indole Derivatives as Anticancer Agent[J]. Chinese Journal of Synthetic Chemistry, 2007, 15(4): 454-458 |
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| Authors: | SHI Chang-qing LIN Wen-qing CHEN Yuan-wei |
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| Affiliation: | 1. Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041 China; 2. Graduate School of Chinese Academy of Sciences, Beijing 100049, China |
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| Abstract: | Novel 2,3-disubstituted indoles as anticancer agents in total yield of 33%~37% were synthesized from o-iodoaniline and phenylethyne by ten-steps reaction.The structures were confirmed by 1H NMR and MS. |
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| Keywords: | anticancer agent indole design drug synthesis |
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