Synthesis and properties of cyanomethyl derivatives of imidazo[1,2-<Emphasis Type="Italic">a</Emphasis>]pyridine,imidazo[1,2-<Emphasis Type="Italic">a</Emphasis>]pyrimidine,and imidazo[2,1-<Emphasis Type="Italic">b</Emphasis>]thiazole |
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Authors: | G P Kutrov N V Kovalenko Yu M Volovenko |
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Institution: | (1) Taras Shevchenko Kiev National University, Kiev, 01033, Ukraine |
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Abstract: | 2-Cyanomethyl derivatives were obtained of imidazo1,2-a]pyridine, imidazo1,2-a]pyrimidine, and imidazo2,1-b]thiazole, and their reactivity was investigated by an example of imidazo1,2-a]pyridine: It was subjected to nitration, bromination, azo coupling and nitrosation. Acylation of the methylene group effected by amino acids esters with a subsequent addition of the amino group to the cyano group resulted in the formation of 5-amino-4-imidazo1,2-a]-pyridin-2-yl-1-phenyl-1,2-dihydro-3H-pyrrol-3-one and 2-amino-1-ethyl-3-imidazol1,2-a]pyridin-2-yl-4(1H)-quinolinone. |
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