PRIOR EXPOSURE OF HUMAN CELLS TO NEAR UV-RADIATION GIVES A DECREASE IN THE AMOUNT OF THE UNSCHEDULED DNA-SYNTHESIS INDUCED BY FAR UV-RADIATION |
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Authors: | M Holmberg |
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Institution: | National Institute of Radiation Protection, Box 60204, 104 01 Stockholm, Sweden |
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Abstract: | Pretreatment of human cells with near UV radiation (UVA) in fluences exceeding 5 × 104 Jm−2 caused a decrease in the amount of the unscheduled DNA synthesis induced by far UV radiation (UVC). The DNA repair synthesis, as measured by the incorporation of 3H] -thymidine, is reduced by nearly a factor of 2 for a UVA radiation exposure of 1.5 × 105 Jm−2. Since solar UVA fluence rate is rather independent of latitude, this figure corresponds to a UVA exposure time of 50-60 min from noon sunlight in the summer time. |
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