| Synthesis,Characterization, and DNA Binding Properties of Dinuclear Copper（Ⅱ） Complex [Cu2（TATP）2（L-Leu）2（CIO4）2]2·2H2O |
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| 作者姓名： | GU Qin ;LIN Qing-bin ;LIU Ying-ju ;LE Xue-yi ;FENG Xiao-long |
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| 作者单位： | [1]Department of Applied Chemistry, College of Sciences, South China Agricultural University, Guangzhou 510642, P. R. China; [2]Center of Analysis and Measurement, Zhongshan University, Guangzhou 510275, P. R. China |
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| 基金项目： | Supported by the Natural Science Foundation of Guangdong Province, China（No. 04105986）. |
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| 摘 要： | A dinuclear copper（Ⅱ） complexCu2（TATP）2（L-Leu）2（CIO4）2]2·2H2Owas synthesized and characterized, where, TATP=1,4,8,9-tetraazatriphenylene, and L-Leu=L-leucinate. The complex was crystallized in the triclinic space group P1, with two independent molecules in a unit cell. Two Cu（Ⅱ） ions in each complex Cu2（TATP）2（L-Leu）2（CIO4）2] molecule were found to be in different coordination geometries, i.e., Cu2 or Cu4 of a distorted square-pyramidal geometry coordinated with two nitrogens of TATP, the amino nitrogen and one carboxylate oxygen of L-Leu and one oxygen of perchlorate, and Cul or Cu3 with an octahedral geometry coordinated with the above stated similar coordinated atoms, and another carboxylate oxygen of L-Leu coordinating to Cu2 or Cu4. The complex can interact with CT-DNA by an intercalative mode and cleave pBR322 DNA in the presence of ascorbate.
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| 关 键 词： | 铜(Ⅱ)配合物 合成 晶体结构 DNA键合 |
| 收稿时间： | 3 August 2007 |
Synthesis, Characterization, and DNA Binding Properties of Dinuclear Copper(II) Complex [Cu2(TATP)2(L-Leu)2(ClO4)2]2·2H2O |
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| GU Qin,;LIN Qing-bin,;LIU Ying-ju,;LE Xue-yi,;FENG Xiao-long.Synthesis, Characterization, and DNA Binding Properties of Dinuclear Copper(II) Complex [Cu2(TATP)2(L-Leu)2(ClO4)2]2·2H2O[J].Chemical Research in Chinese University,2008,24(4):401-406. |
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| Authors: | Qin GU Ying-ju LIU Xiao-long FENG |
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| Institution: | a Department of Applied Chemistry, College of Sciences, South China Agricultural University, Guangzhou 510642, P. R. China
b Center of Analysis and Measurement, Zhongshan University, Guangzhou 510275, P. R. China |
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| Abstract: | A dinuclear copper(II) complex Cu2(TATP)2(L-Leu)2(ClO4)2]2·2H2O was synthesized and characterized, where, TATP=1,4,8,9-telraazatriphenylene, and L-Leu=L-leucinate. The complex was crystallized in the triclinic space group p1, with two independent molecules in a unit cell. Two Cu(II) ions in each complex Cu2(TATP)2(L-Leu)2(ClO4)2] molecule were found to be in different coordination geometries, i.e., Cu2 or Cu4 of a distorted square-pyramidal geometry coordinated with two nitrogens of. TATP, the amino nitrogen and one carboxylate oxygen of L-Leu and one oxygen of perchlorate, and Cul or Cu3 with an octahedral geometry coordinated with the above stated similar coordinated atoms, and another carboxylate oxygen of L-Leu coordinating to Cu2 or Cu4. The complex can interact with CT-DNA by an intercalativc mode and cleave pBR322 DNA in the presence of ascorbatc. |
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| Keywords: | Copper(II) complex 1 4 8 9-Tetraazatriphenylene L-Leucinate DNA |
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