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Synthesis of thiourea derivatives as CCR4 antagonists |
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| Authors: | Fang Zhao Jun Hai Xiao Ying Wang c Song Lib a School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang China b Institute of Pharmacology Toxicology Academy of Military Medical Sciences Beijing China c Center for Human Disease Genomics Peking University Beijing China |
| Affiliation: | a School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China;b Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China;c Center for Human Disease Genomics, Peking University, Beijing 100083, China |
| Abstract: | A series of thiourea derivatives have been synthesized. Their structures were confirmed by MS and 1H NMR. Several compounds showed potent activities as antagonists of CCR4 receptor. |
| Keywords: | CCR4 antagonists Thiourea derivatives Synthesis |
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