| 基于金@二氧化锰纳米片超级纳米粒子从比色到单颗粒光谱检测谷胱甘肽 |
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| 引用本文： | 凌云云,李莉,梁修蓉,夏云生.基于金@二氧化锰纳米片超级纳米粒子从比色到单颗粒光谱检测谷胱甘肽[J].高等学校化学学报,2020,41(4):623-632. |
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| 作者姓名： | 凌云云 李莉 梁修蓉 夏云生 |
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| 作者单位： | 1. 安徽师范大学化学与材料科学学院, 教育部功能分子固体重点实验室, 芜湖 241000;2. 皖南医学院药学院, 医用基础化学教研室, 芜湖 241000 |
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| 基金项目： | 国家自然科学基金(批准号:21775004)和皖南医学院中青年科研项目(批准号:WK201512)资助. |
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| 摘 要： | 合成了由金纳米球和二氧化锰薄片组成的金@二氧化锰纳米片超级纳米粒子(AMNS-SPs), 将其作为探针, 利用比色和单颗粒光谱2种分析方法进行了谷胱甘肽的传感检测. 该传感检测基于选择性刻蚀探针AMNS-SPs中的二氧化锰纳米片, 使得该探针的局域表面等离子共振波长蓝移. 实验结果表明, 比色法和单颗粒光谱法检测谷胱甘肽的检出限分别为0.018 μmol/L和23.2 fmol/L, 且后者是目前检测谷胱甘肽灵敏度最高的传感方法之一. 该传感方法的优异性能主要源于非常薄的二氧化锰纳米片.
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| 关 键 词： | 谷胱甘肽 比色 裸眼检测 单颗粒光谱 |
| 收稿时间： | 2019-12-18 |
Glutathione Sensing:from Colorimetry to Single Particle Spectroscopy Based on Gold NP@MnO 2 Nanosheets Supraparticles |
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| LING Yunyun,LI Li,LIANG Xiurong,XIA Yunsheng.Glutathione Sensing:from Colorimetry to Single Particle Spectroscopy Based on Gold NP@MnO 2 Nanosheets Supraparticles[J].Chemical Research In Chinese Universities,2020,41(4):623-632. |
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| Authors: | LING Yunyun LI Li LIANG Xiurong XIA Yunsheng |
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| Institution: | 1. Key Laboratory of Functional Molecular Solids, Ministry of Education, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, China;2. Department of Medical General Chemistry, School of Pharmacy, Wannan Medical College, Wuhu 241002, China |
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| Abstract: | We herein study glutathione(GSH)sensing by two kinds of assay modes,namely colorimetry and single particle spectroscopy,using the as-prepared hybrid supraparticles made of gold nanoparticles and MnO 2 nanosheets(denoted as AMNS-SPs)as probes.The sensing is based on the selective etching of decorated MnO 2 nanosheets,which causes a substantial blue shift of the localized surface plasmon resonance of the AMNS-SPs.In terms of the two sensing systems,the detection limits are 0.018μmol/L and 23.2 fmol/L,respectively.To our knowledge,the latter is one of the highest sensitivity for GSH sensing.This favorable performance is attributed to a rather thin thickness of the decorated MnO 2 nanosheets. |
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| Keywords: | Glutathione Colorimetric Naked eye detection Single particle spectroscopy |
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