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内生真菌叶下珠生拟茎点霉的次级代谢产物研究(英文)
引用本文:刘洪新,李浩华,陈玉蝉,谭海波,章卫民.内生真菌叶下珠生拟茎点霉的次级代谢产物研究(英文)[J].有机化学,2019(5):1475-1478.
作者姓名:刘洪新  李浩华  陈玉蝉  谭海波  章卫民
作者单位:广东省微生物研究所省部共建华南应用微生物国家重点实验室广东省菌种保藏与应用重点实验室广东省微生物应用新技术公共实验室;中国科学院华南植物园
基金项目:Project supported by the National Natural Science Foundation of China(No.31600271);the Guangdong Provincial Project for Science and Technology(No.2107A020211023);the Pearl River Science and Technology New Star Fund of Guangzhou City(No.201806010080)~~
摘    要:从广藿香内生真菌叶下珠生拟茎点霉(Phomopsis phyllanthicola A658)中分离纯化得到6个聚酮类化合物,分别鉴定为dothiorelone O(1),2-3,5-二羟基-2-(7-羟基辛酰基)苯基]乙酸(2),dothiorelone M(3),dothiorelone K(4),cytosporone B(5),和cytosporone C(6).其中化合物1为新化合物,化合物2为新天然产物,新化合物的结构进一步通过HR-ESIMS,1D NMR和2D NMR等光谱技术确定.此外,对分离所得的化合物进行了体外细胞毒测试,结果表明化合物3~5显示出不同程度的细胞毒活性.

关 键 词:广藿香  内生真菌  叶下珠生拟茎点霉  细胞毒活性

Cytotoxic Secondary Metabolites from an Endophytic Fungal Strain of Phomopsis phyllanthicola
Liu Hongxin,Li Haohua,Chen Yuchan,Tan Haibob,Zhang Weimin.Cytotoxic Secondary Metabolites from an Endophytic Fungal Strain of Phomopsis phyllanthicola[J].Chinese Journal of Organic Chemistry,2019(5):1475-1478.
Authors:Liu Hongxin  Li Haohua  Chen Yuchan  Tan Haibob  Zhang Weimin
Institution:(State Key Laboratory of Applied Microbiology Southern Chin,Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070;South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650)
Abstract:Liu Hongxin;Li Haohua;Chen Yuchan;Tan Haibob;Zhang Weimin(State Key Laboratory of Applied Microbiology Southern Chin,Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070;South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650)
Keywords:Pogostemon cablin  endophytic fungus  Phomopsis phyllanthicola  cytotoxicity
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