Reaction of the zinc enolate derived from 1,1-dibromo-3,3-dimethylbutan-2-one with 3-aryl-2-cyanopropenoic acid amides and esters and 2-oxochromene-3-carboxamides |
| |
Authors: | V V Shchepin P S Silaichev Yu G Stepanyan K P Lebedev M I Vakhrin |
| |
Institution: | (1) Perm State University, ul. Bukireva 15, Perm, 614990, Russia |
| |
Abstract: | Zinc enolate derived from 1,1-dibromo-3,3-dimethylbutan-2-one reacts with 3-aryl-2-cyanoprop-2-enamides and aryl 3-aryl-2-cyanoprop-2-enoates to give the corresponding derivatives of 3-aryl-2-(2,2-dimethylpropanoyl)-1-cyanocyclopropane-1-carboxylic acid as a single stereoisomer with cis arrangement of the hydrogen atoms at the cyclopropane ring. The reactions of the same zinc enolate with 3-morpholinocarbonyl-2H-chromen-2-one and 2-morpholinocarbonyl-3H-benzof]chromen-3-one lead to formation of 1-(2,2-dimethylpropanoyl)-1a-morpholinocarbonyl-1a,7b-dihydrocyclopropac]chromen-2-one and 1-(2,2-dimethylpropanoyl)-1a-morpholinocarbonyl-1a,9c-dihydrobenzof]cyclopropac]chromen-2-one, respectively as a single stereoisomer. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|