Total synthesis of ionomycin using ring-opening strategies |
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| Authors: | Lautens Mark Colucci John T Hiebert Sheldon Smith Nicholas D Bouchain Giliane |
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| Institution: | Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St. George St., Toronto, Ontario M5S 3H6, Canada. mlautens@chem.utoronto.ca |
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| Abstract: | structure: see text] The total synthesis of the polyether antibiotic ionomycin, a calcium ionophore, is described. The synthesis demonstrates the utility of ring-opening methodologies as applied to the synthesis of polypropionate and deoxypolypropionate subunits, which are found in two of the four fragments in the synthesis. |
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