| 新型氮芥和卤代烷基哌嗪芳香醛的合成 |
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| 引用本文： | 郭灿城,李可来,童荣标,陈亮,张晓兵. 新型氮芥和卤代烷基哌嗪芳香醛的合成[J]. 有机化学, 2005, 25(3): 308-312 |
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| 作者姓名： | 郭灿城 李可来 童荣标 陈亮 张晓兵 |
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| 作者单位： | 湖南大学,化学化工学院,长沙,410082 |
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| 基金项目： | 国家自然科学基金，国家高技术研究发展计划(863计划) |
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| 摘 要： | 通过对Vilsmeier反应、烷基化反应和氯化反应的改进提出了以简单易得的苯胺和苯基哌嗪为原料制备氮芥和哌嗪芳香醛的方法. 采用该改进的方法合成了8个氮芥和哌嗪芳香醛, 其中7个为新化合物. 它们的结构均经质谱、红外光谱、核磁共振谱和元素分析确证.
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| 关 键 词： | 合成 芳香醛 氮芥 哌嗪 Vilsmeier反应 |
| 收稿时间： | 2004-01-12 |
| 修稿时间： | 2004-01-12 |
Synthesis of New Aromatic Aldehydes Bearing Nitrogen Mustard Derivatives and Halogenoalkylpiperazinyl |
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| GUO Can-Cheng,LI Ke-Lai,TONG Rong-Biao,CHEN Liang,ZHANG Xiao-Bing. Synthesis of New Aromatic Aldehydes Bearing Nitrogen Mustard Derivatives and Halogenoalkylpiperazinyl[J]. Chinese Journal of Organic Chemistry, 2005, 25(3): 308-312 |
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| Authors: | GUO Can-Cheng LI Ke-Lai TONG Rong-Biao CHEN Liang ZHANG Xiao-Bing |
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| Affiliation: | (College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082) |
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| Abstract: | Modifications of alkylation, chlorination and Vilsmeier reaction were employed for the synthesis of aromatic aldehydes bearing nitrogen mustard derivatives and halogenoalkylpiperazinyl. Thus seven new aromatic aldehydes were synthesized from commercially available aniline and phenylpiperazine by the modified method. All of the desired compounds were characterized by MS, IR, H NMR spectra and ele- 1 mental analysis. |
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| Keywords: | synthesis aromatic aldehyde nitrogen mustard piperazine Vilsmeier reaction |
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