Diaryl ethers using Fischer chromium carbene mediated benzannulation |
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Authors: | Pulley S R Sen S Vorogushin A Swanson E |
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Institution: | Department of Chemistry, University of Missouri-Columbia 65211-7600, USA. pulleys@missouri.edu |
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Abstract: | formula: see text] The biological relevance and irresistible synthetic challenge of compounds containing the diaryl ether linkage encourages the development of new methodologies targeted toward this structural subunit. The syntheses of diaryl ethers 2 using a benzannulation strategy that formally involves a 3 + 2 + 1] cycloaddition between aryloxy-substituted Fischer carbenes 1 and alkynes are described. This methodology provides a neutral near ambient temperature formation of diaryl ethers. |
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