Solid-phase oligosaccharide synthesis: preparation of complex structures using a novel linker and different glycosylating agents |
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| Authors: | Andrade R B Plante O J Melean L G Seeberger P H |
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| Institution: | Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139, USA. |
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| Abstract: | formula: see text] A beta-(1-->4)-linked trisaccharide was prepared in 53% yield on a polymer support using glycosyl phosphates and released by cross-metathesis of a novel linker to reveal the anomeric n-pentenyl glycoside. Heptasaccharide 33 was prepared in 9% yield in 14 steps. |
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