New bis(1-ferrocenylethyl)amine-derived monodentate phosphoramidite ligands for highly enantioselective copper-catalyzed 1,4-conjugate addition |
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| Authors: | Dong-Yun Zou Zheng-Chao Duan Xiang-Ping Hu Zhuo Zheng |
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| Institution: | 1. China Agricultural University, Beijing 100094, China;2. Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China |
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| Abstract: | A new family of chiral bis(1-ferrocenylethyl)amine-derived monodentate phosphoramidite ligands has been prepared and successfully applied in the Cu-catalyzed asymmetric 1,4-conjugate addition of diethylzinc to a variety of α,β-unsaturated compounds, in which up to 99% ee was obtained for nitroalkenes at ?78 °C and >98% ee for cyclohexenone at ?30 °C, comparable to or higher than those obtained with the most efficient monophosphoramidite ligands reported so far. |
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