Palladium-catalyzed asymmetric allylic nucleophilic substitution reactions using chiral tert-butanesulfinylphosphine ligands |
| |
| Authors: | Junmin Chen Feng Lang Dong Li Linfeng Cun Jin Zhu Jingen Deng Jian Liao |
| |
| Affiliation: | 1. National Engineering Research Center of Chiral Drugs and Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China;2. Graduate School of Chinese Academy of Sciences, Beijing 100049, China;3. College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, China |
| |
| Abstract: | The asymmetric allylic alkylation of racemic 1,3-diphenyl-2-propenyl acetate 3 with dimethyl malonate proceeded smoothly in the presence of lithium acetate, BSA (N,O-bis(trimethylsilyl)acetamide), [Pd(η3-C3H5)Cl]2, and chiral tert-butanesulfinylphosphine ligand 2c to give the allylic alkylation product in good yield and high enantiomeric excess (up to 93% ee), while the enantioselectivities of allylic amination of 3 with various amines were moderate (up to 76% ee). |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
