Recent progress in improving the performance of in vivo electrochemical microsensor based on materials

In vivo monitoring of neurochemicals is important for exploring the mechanism and function of the central nervous system. In vivo electrochemical microsensor benefiting from high temporal and spatial resolution has been demonstrated to be one effective strategy for neurochemical detection. However, due to the complex biological environment, microsensor faces huge challenges in sensitivity, selectivity, stability, and biocompatibility. Materials with good electron-transfer, rough surface, and easy functionalization are widely used to enhance the performance of microsensor. In this review, we summarize the recent progress in improving the performance of in vivo electrochemical microsensor based on materials.