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Global variations in peak bone mass as studied by dual-energy X-ray absorptiometry |
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| Authors: | E V McCloskey A Dey R M Parr N Aras A Balogh J Bostock A Borell S Krishnan G Lobo L L Qin Y Zhang S Cvijetic V Zaichick M Lim-Abraham K Bose S Wynchank G V Iyengar |
| Institution: | 1. WHO Collaborating Centre for Metabolic Bone Diseases, Sheffield, UK E-mail 2. IAEA, Vienna, Austria 3. University of Bahcesehir, 34538, Istanbul, Turkey 4. University of Debrecen, Debrecen, Hungary 5. Hospital das Clinicas, Sao Paulo, Brazil 6. Toronto General Hospital, Toronto, ON, Canada 7. Clinica Indisa, Santiago, Chile 8. China-Japan Friendship Hospital, Beijing, P.R. China 9. Institute of Nuclear Research, Shanghai, P.R. China 10. Institute for Medical Research, Zagreb, Croatia 11. Medical Radiological Research Centre, Obninsk, 249020, Russia 12. PGH Medical Centre, Manila, Philippines 13. National University Hospital, Singapore, Singapore 14. Medical Research Council, Tygerberg, South Africa |
| Abstract: | In 1994, the International Atomic Energy Agency (IAEA) initiated a 5-year Co-ordinated Research Project (CRP) to determine geographical and racial differences in peak bone mineral density (BMD) in men and women aged 15-49 years. The study demonstrates that there are distinct global differences in BMD at the hip and spine in both men and women approximating to one population standard deviation between populations with the highest and lowest BMD. These differences persist following adjustments for age, sex and body size. Such information is valuable in understanding the reasons for global differences in fracture rate and predicting future trends in fracture incidence. This revised version was published online in August 2006 with corrections to the Cover Date. |
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