Synthesis and antioxidant activity of new hydroxy derivatives of chalcones |
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Authors: | Osipova V P Polovinkina M A Telekova L R Velikorodov A V Stepkina N N Berberova N T |
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Institution: | 1.Federal Scientific Center “Southern Scientific Center of the Russian Academy of Sciences”,, 41 prosp. Chekhova, 344006, Rostov-on-Don, Russian Federation ;2.Astrakhan State Technical University, 16 ul. Tatishcheva, 414056, Astrakhan, Russian Federation ;3.Astrakhan State University, 20a ul. Tatishcheva, 414056, Astrakhan, Russian Federation ; |
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Abstract: | New hydroxy derivatives of chalcones obtained via a condensation of 3-acetyl-2H-chromen-2-one with 2,4-dihydroxy- and 4-hydroxy-benzaldehydes and via an aldol crotonic condensation of methyl N-(4-acetylphenyl)carbamate with 4-hydroxy-3,5-di(tert-butyl)benzaldehyde have been isolated and characterized. A wide range of promising biological activity of the synthesized compounds, including the radical scavenging and antioxidant ones, was predicted by the in silico method. The anti- and pro-oxidant activities in model systems of peroxidation of cis-9-octadecenoic (oleic) acid and lipids from the liver homogenate of tilapia were estimated in vitro. The presence of sterically hindered hydroxy groups and a chromene moiety provides the prolonged antioxidant activity of new hydroxy derivatives of chalcones. |
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