EFFECTS OF CAFFEINE ON DNA REPAIR OF UV-IRRADIATED DICTYOSTELIUM DISCOIDEUM |
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| Authors: | T Ohnishi K Okaichi Y Ohashi K Nozu |
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| Institution: | Department of Biology, Nara Medical College, Kashihara, Nara 634, Japan |
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| Abstract: | Abstract— Caffeine enhances the UV-killing of amoeboid cells of NC-4, but UV-irradiated γs-13 is insensitive to caffeine. UV-irradiated NC-4 becomes insensitive to the effect of caffeine during a postirradiation incubation in buffer for about 90 min, but γs-13 remains unchanged in the sensitivity to caffeine throughout the incubation for 180 min. Amoeboid cells of γs-13 can remove pyrimidine dimers as well as NC-4 even in the presence of caffeine. Caffeine inhibits rejoining of strand-breaks of DNA in UV-irradiated NC-4, but the rejoining in γs-13 is insensitive to caffeine. |
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