Utilization of maltodextrin based enantioselective, potentiometric membrane electrodes for the enantioselective assay of S-perindopril |
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| Authors: | Ozoemena Kenneth I Stefan Raluca-Ioana van Staden Jacobus F Aboul-Enein Hassan Y |
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| Affiliation: | a Department of Chemistry, University of Pretoria, Pretoria 0002, South Africa
b Pharmaceutical Analysis and Drug Development Laboratory, Biological and Medical Research Department (MBC-03-65), King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, Riyadh 11211, Saudi Arabia |
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| Abstract: | Enantioselective, potentiometric membrane electrodes (EPMEs) based on carbon paste impregnated with different maltodextrins {dextrose equivalent (DE) 4.0-7.0 (I), 13.0-17.0 (II) and 16.5-19.5 (III)} as chiral selectors for the assay of S-perindopril is described. The proposed electrodes could be reliably employed in the assay of S-perindopril raw material and from its pharmaceutical formulation, Coversyl® tablets. The electrode based on maltodextrin (I) showed the best enantioselectivity and time-stability. The surfaces of the electrodes are easily renewable by simply polishing on an alumina paper. |
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| Keywords: | Enantioselective, potentiometric membrane electrode Enantioanalysis Maltodextrins S-Perindopril |
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