Far‐Red and Near‐IR AIE‐Active Fluorescent Organic Nanoprobes with Enhanced Tumor‐Targeting Efficacy: Shape‐Specific Effects |
| |
| Authors: | Andong Shao Prof. Dr. Yongshu Xie Shaojia Zhu Dr. Zhiqian Guo Shiqin Zhu Dr. Jin Guo Prof. Dr. Ping Shi Prof. Dr. Tony D. James Prof. Dr. He Tian Prof. Dr. Wei‐Hong Zhu |
| |
| Affiliation: | 1. Key Laboratory for Advanced Materials and Institute of Fine Chemicals, Shanghai Key Laboratory of Functional Materials Chemistry, State Key Laboratory of Bioreactor Engineering, Collaborative Innovation Center for Coal Based Energy (i‐CCE), East China University of Science & Technology, Shanghai 200237 (China);2. PerkinElmer Instruments (Shanghai) Co. Zhangheng Road 1670 Shanghai 201203 (China);3. Department of Chemistry, University of Bath, Bath BA2 7AY (UK) |
| |
| Abstract: | ![]()
The rational design of high‐performance fluorescent materials for cancer targeting in vivo is still challenging. A unique molecular design strategy is presented that involves tailoring aggregation‐induced emission (AIE)‐active organic molecules to realize preferable far‐red and NIR fluorescence, well‐controlled morphology (from rod‐like to spherical), and also tumor‐targeted bioimaging. The shape‐tailored organic quinoline–malononitrile (QM) nanoprobes are biocompatible and highly desirable for cell‐tracking applications. Impressively, the spherical shape of QM‐5 nanoaggregates exhibits excellent tumor‐targeted bioimaging performance after intravenously injection into mice, but not the rod‐like aggregates of QM‐2. |
| |
| Keywords: | aggregation‐induced emission fluorescent probes morphology effects near infrared tumor targeting |
|
|
