|
|||||
|
|
Novel Mechanism of Bioluminescence: Oxidative Decarboxylation of a Moiety Adjacent to the Light Emitter of Fridericia Luciferin |
|
| Authors: | Maxim A Dubinnyi Zinaida M Kaskova Natalja S Rodionova Mikhail S Baranov Andrey Yu Gorokhovatsky Alexey Kotlobay Kyril M Solntsev Aleksandra S Tsarkova Valentin N Petushkov Ilia V Yampolsky |
| Institution: | 1. Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho‐Maklaya 16/10, Moscow 117997 (Russia) http://yampolsky.ibch.ru;2. Pirogov Russian National Research Medical University, Ostrovitianov 1, Moscow 117997 (Russia);3. Laboratory of Photobiology, Institute of Biophysics, Siberian Branch of the Russian Academy of Sciences, Akademgorodok, Krasnoyarsk 660036 (Russia);4. Branch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Nauki Prosp. 6, Pushchino, 142290 (Russia);5. School of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA 30332‐0400 (USA) |
| Abstract: | A novel luciferin from a bioluminescent Siberian earthworm Fridericia heliota was recently described. In this study, the Fridericia oxyluciferin was isolated and its structure elucidated. The results provide insight into a novel bioluminescence mechanism in nature. Oxidative decarboxylation of a lysine fragment of the luciferin supplies energy for light generation, while a fluorescent CompX moiety remains intact and serves as the light emitter. |
| Keywords: | bioluminescence bioorganic chemistry luciferin oxidative decarboxylation peptides |