Development of Chiral Spiro P‐N‐S Ligands for Iridium‐Catalyzed Asymmetric Hydrogenation of β‐Alkyl‐β‐Ketoesters |
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| Authors: | Deng‐Hui Bao Hui‐Ling Wu Chao‐Lun Liu Prof Jian‐Hua Xie Prof Qi‐Lin Zhou |
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| Institution: | State Key Laboratory and Institute of Elemento‐organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071 (China) http://zhou.nankai.edu.cn |
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| Abstract: | The chiral tridentate spiro P‐N‐S ligands (SpiroSAP) were developed, and their iridium complexes were prepared. Introduction of a 1,3‐dithiane moiety into the ligand resulted in a highly efficient chiral iridium catalyst for asymmetric hydrogenation of β‐alkyl‐β‐ketoesters, producing chiral β‐alkyl‐β‐hydroxyesters with excellent enantioselectivities (95–99.9 % ee) and turnover numbers of up to 355 000. |
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| Keywords: | asymmetric catalysis hydrogenation iridium ketoesters spiro ligands |
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