Nonpeptidic foldamers from amino acids: synthesis and characterization of 1,3-substituted triazole oligomers |
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Authors: | Angelo Nicholas G Arora Paramjit S |
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Institution: | Department of Chemistry, New York University, New York, New York 10003, USA. |
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Abstract: | Nonpeptidic foldamers capable of displaying protein-like functionality were prepared by swapping amide bonds with 1,2,3-triazole rings. The overall conformation of these triazole oligomers is largely dictated by dipole-dipole interactions between adjacent rings. Solution NMR studies suggest that a zigzag conformation, which closely mimics the beta-strand structure, predominates in two different tetramers. |
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