Multicomponent Domino [4+1+1] Carbocyclization Providing an Efficient and Regioselective Strategy to Fluoren-9-ones |
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Authors: | Ying Li Haiwei Xu Liping Fu Qingqing Shi Bo Jiang Shujiang Tu |
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Institution: | School of Chemistry and Chemical Engineering, Laboratory of Green Synthetic Chemistry for Functional Materials,Jiangsu Normal University, Xuzhou, Jiangsu 221116, China |
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Abstract: | Concise and efficient three‐component domino 4+1+1] carbocyclization to highly substituted fluoren‐9‐one derivatives promoted by K2CO3 has been developed under microwave irradiation conditions. The direct bis‐cyanation and aryl amination residing in fluoren‐9‐one framework were achieved in a one‐pot operation. The reaction proceeds at fast rates and can be finished within 30 min, which makes workup convenient to give good to excellent chemical yields. |
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Keywords: | fluoren-9-one synthesis multicomponent reactions carbocyclization regioselectivity microwave heating |
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